Fentanyl Pills (also known as fentanil) is a potent, synthetic opioid pain medication with a rapid onset and short duration of action. It is a strong agonist at the μ-opioid receptors. Fentanyl is estimated to be between 50 and 100 times as potent as morphine.
Fentanyl Pills was first made by Paul Janssen in 1960, following the medical inception of pethidine (also known as meperidine, marketed as Demerol) several years earlier. Janssen developed fentanyl by assaying analogues of the structurally related drug pethidine for opioid activity. The widespread use of fentanyl triggered the production of fentanyl citrate (the salt form by combining fentanyl and citric acid in a 1: 1 stoichiometry), which entered the medical field as a general anesthetic under the trade name Sublimaze in the 1960s. Following this, many other fentanyl analogues have been developed and introduced into medical practice, including sufentanil, alfentanil, remifentanil, and lofentanil.
Fentanyl Pills In the mid-1990s, fentanyl was introduced for palliative use with the fentanyl patch, followed in the next decade by the introduction of fentanyl lollipop, dissolving tablets, and sublingual spray which are resorbed through the skin inside the mouth. 2012 fentanyl was the most widely used synthetic opioid in medicine.In 2013, 1700 kilograms were used globally.
Fentanyl is also used as a recreational drug and this use has resulted in thousands of overdose deaths each year in recent years. The deaths also resulted from medical misuse. Fentanyl has a relatively broad therapeutic index (270), making it a very safe surgical anesthetic when closely monitored; However, its extreme potency requires careful measurements of highly diluted fentanyl in solution; attempting to accurately measure a dose of pure fentanyl powder is not practical without advanced scientific equipment, since an effective dose and a lethal dose of fentanyl powder placed next to each other would be difficult or impossible to differentiate at the same time. naked eye.
Fentanyl can slow down or stop breathing and may be addictive. MISUSE OF A NARCOTIC MEDICINAL PRODUCT MAY CAUSE DRUG ABUSE, OVERDOSE OR DEATH, especially in a child or other person using the drug without a prescription.
The use of this medication during pregnancy can cause potentially life-threatening withdrawal symptoms in the newborn.
Fatal side effects may occur if you use this medication with alcohol or other drugs that cause drowsiness or slow breathing.
Before taking this medicine
You should not use fentanyl unless you have recently taken an opioid medication and your body is tolerant to it (see your doctor if you are not sure).
Do not put fentanyl skin patch on anyone who does not have a personal prescription for this medicine. You should not use fentanyl if you are allergic to it or if you have:
severe asthma or other respiratory problems; or
an obstruction of the stomach or intestine (including paralytic ileus).
To make sure that fentanyl patches are safe for you, tell your doctor if you have ever had:
breathing problems, sleep apnea;
head injury, brain tumor or mental illness;
alcoholism or drug addiction;
an epileptic seizure, liver or kidney disease; gall bladder, pancreas or thyroid problems.
If you have had a fever, tell your doctor. High temperature can increase the amount of medicine you absorb through your skin.
If you use an opioid while you are pregnant, your baby may become addicted to the drug. This can cause withdrawal symptoms that endanger the baby’s life after birth. Infants born with opioids may require medical treatment for several weeks.